IMR Press / FBL / Volume 19 / Issue 8 / DOI: 10.2741/4294

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Synthesis and degradation of poly(ADP-ribose) in plants

Show Less
1 Department of Biology, University of Naples “ Federico II”, Naples, Italy
Academic Editor:Maria Rosaria Faraone-Mennella
Front. Biosci. (Landmark Ed) 2014, 19(8), 1436–1444;
Published: 1 June 2014
(This article belongs to the Special Issue Synthesis and degradation of polyADP-ribose in plants)

Poly(ADP-ribosylation) is a post-translational modification of proteins involved in a wide range of molecular and cellular processes in mammalian system. The main enzymes responsible for this modification are the poly(ADP-ribose) polymerases that catalyze the transfer of ADP ribose moieties from NAD+ to target protein acceptors, producing long and branched ADP-ribose polymers. The poly(ADP ribosyl)ation is rapidly reverted by poly(ADP-ribose) glycohydrolase enzymes, which hydrolyzes poly(ADP-ribose) polymers, generating free ADP-ribose. So far, nine proteins with a poly(ADP-ribose) polymerase signature and two poly(ADP-ribose) glycohydrolase enzymes encoded by two adiacent genes were identified in Arabidopsis. The present review will describe the structures and functions of plant poly(ADP- ribose) polymerases and poly(ADP-ribose) glycohydrolases.

Back to top