IMR Press / FBL / Volume 19 / Issue 8 / DOI: 10.2741/4283

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Calorie restriction and NAD⁺/sirtuin counteract the hallmarks of aging
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1 Instituto Nacional de Geriatria, Institutos Nacionales de Salud, D. F., Mexico
Academic Editor:Antoni Camins
Front. Biosci. (Landmark Ed) 2014, 19(8), 1300–1319; https://doi.org/10.2741/4283
Published: 1 June 2014
(This article belongs to the Special Issue Current advances in epilepsy and neurodegeneration)
Abstract

Among diverse environmental factors that modify aging, diet has a profound effect. Calorie restriction (CR), which entails reduced calorie consumption without malnutrition, is the only natural regimen shown to extend maximum and mean lifespan, as well as healthspan in a wide range of organisms. Although the knowledge about the biological mechanisms underlying CR is still incipient, various approaches in biogerontology research suggest that CR can ameliorate hallmarks of aging at the cellular level including telomere erosion, epigenetic alterations, stem cells depletion, cellular senescence, mitochondrial dysfunction, genomic instability, proteostasis imbalance, impaired nutrient sensing and abnormal intercellular communication. Currently, the NAD+/sirtuin pathway is one of the few mechanisms described to mediate CR effects and sirtuin-activating compounds (STACs) mimic many effects of CR. Herein, we discuss the effects of CR on healthspan with emphasis on neuroprotection, how CR counteracts cellular aging, how sirtuin pathways intertwine with CR, and the relevance of STACs in mimicking CR effects.

Keywords
Calorie restriction
Sirtuins
Healthspan
Longevity
Neuroprotection
Sirtuin-Activating Compounds
Resveratrol
Aging
Review
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