IMR Press / FBL / Volume 19 / Issue 7 / DOI: 10.2741/4269

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
The role of molecular biology in the diagnosis of lymphoid neoplasms
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1 Department of Medicine, DIMED, General Pathology,Cytopathology Unit, University of Padova, Padova, Italy
2 Hematopathology, Haematology Sections, Department of Experimental, Diagnostic and Specialty Medicine, Sant'Orsola, Malpighi Hospital, University of Bologna, Bologna, Italy
Academic Editor:Matteo Fassan
Front. Biosci. (Landmark Ed) 2014, 19(7), 1088–1104; https://doi.org/10.2741/4269
Published: 1 June 2014
(This article belongs to the Special Issue The post-genomic revolution in diagnostic pathology)
Abstract

In recent years, DNA-arrays, gene expression profiling and next-generation sequencing have elucidated the high complexity of genomic alterations occurring in lymphoid malignancies. These studies have also contributed to the identification of new diagnostic and prognostic biomarkers, which may represent possible targets for new therapeutic approaches. Such recent advances have significantly expanded the application of molecular tests to routine diagnostic hematopathology. It is thus conceivable that next-generation assays will soon flank traditional clonality tests and chromosomal translocation assays in the diagnostic work-up of difficult cases. This review is focused on the application of molecular biology techniques in the study of lymphoid tumors. Both conventional and next-generation tests will be addressed, with particular attention to their application to clinical practice.

Keywords
Non-Hodgkin Lymphoma
Molecular Biology
Clonality Test
DNA-arrays
Genome Expression Profiling
Next-Generation Sequencing
Review
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