IMR Press / FBL / Volume 19 / Issue 5 / DOI: 10.2741/4248

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Oxidative DNA damage - the possible use of biomarkers as additional prognostic factors in oncology
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1 Department of Radiotherapy, the F. Lukaszczyk Oncology Center Bydgoszcz, Romanowskiej 2, 85-796 Bydgoszcz, Poland
Academic Editor:Wei Qin
Front. Biosci. (Landmark Ed) 2014, 19(5), 808–817; https://doi.org/10.2741/4248
Published: 1 January 2014
(This article belongs to the Special Issue Pathogenesis and diagnostic modalities in cancer)
Abstract

Oxidative stress represents a deregulation of the homeostasis between the reactive oxygen species and the mechanisms of detoxification and repair. By analyzing the level of oxidatively damaged DNA bases and nucleosides in urine we can assess the extent of DNA repair within the whole body. High levels of markers of oxidative DNA damage excreted in the urine indicate elevated levels of oxidative stress, but can also reflect a high level of efficiency of the processes that work to repair this damage (oxidative stress can be high and the repair processes eliminate its effects). In the present review we discuss the role of oxidative stress, oxidative DNA damage repair mechanisms, potential sources of 8-oxoGua and 8-oxodG (basic markers of oxidative stress) content in urine, effect of antioxidant supplementation on the levels of oxidative DNA lesions, potential application of oxidative DNA damage determination in clinical practice.


Keywords
oxidative DNA damage
biomarkers
8- oxoGua
8-oxodG
prognostic factors
cancer patients
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