IMR Press / FBL / Volume 17 / Issue 3 / DOI: 10.2741/3965

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Regulation of inducible gene expression by natural antisense transcripts
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1 Department of Biomedical Sciences, College of Life Sciences, Kusatsu, Shiga, Japan
2 Research Organization of Science and Technology, Kusatsu, Shiga, Japan
3 Department of Pharmacy, College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan
4 Department of Surgery, Kansai Medical University, Hirakata, Osaka, Japan
Academic Editor:Tominori Kimura
Front. Biosci. (Landmark Ed) 2012, 17(3), 938–958; https://doi.org/10.2741/3965
Published: 1 January 2012
(This article belongs to the Special Issue Regulatory long non-coding RNA)
Abstract

Natural antisense transcripts are frequently transcribed from many genes in eukaryotes. Although natural antisense transcripts have been recognized for a long time, their importance has been overlooked due to their heterogeneity, low expression level, and unknown function. Genes induced in responses to various external stimuli are transcriptionally regulated by the activation of a gene promoter and post-transcriptionally regulated by controlling mRNA stability and translatability. Recent studies have shed light on the functions of natural antisense transcripts at the post-transcriptional level. An antisense transcript may regulate gene expression with cis-controlling elements on the mRNA, and the antisense transcript itself may act in concert with trans-acting factors, including various proteins that bind to cis-controlling elements, drugs, and microRNAs. A novel mechanism recently reported to regulate mRNA stability includes the interaction of the antisense transcript with mRNA by hybridization to single-stranded loops in secondary structures. This antisense transcript-mediated post-transcriptional regulation may be one of the general mechanisms for the regulation of inducible gene expression and presents the possibility of the involvement of natural antisense transcripts in disease.

Keywords
Natural antisense transcript
mRNA stability
RNA-RNA interaction
RNA-protein Interaction
Secondary Structure
Review
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