IMR Press / FBL / Volume 17 / Issue 1 / DOI: 10.2741/3928

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Genome-wide impact of endogenous antisense transcripts in eukaryotes
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1 Technology and Development Team for Mammalian Cellular Dynamics, BioResource Center (BRC), RIKEN Tsukuba Institute, Ibaraki, 305–0074, Japan
2 Transdisciplinary Research Integration Center, Research Organization of Information and Systems, National Institute of Genetics, Mishima, Shizuoka, 411–8540, Japan
Academic Editor:Tominori Kimura
Front. Biosci. (Landmark Ed) 2012, 17(1), 300–315;
Published: 1 January 2012
(This article belongs to the Special Issue Regulatory long non-coding RNA)

Recent transcriptomic studies revealed that extensive proportions of genomes are transcribed, despite the limited fraction of protein-coding gene loci in the whole genome. Most transcripts are considered to be 'cryptic' output of the genome because of the lack of functional evidence; however, recent progress in molecular analyses has revealed that some of these transcripts at least have functional significance. This review article examines evidence of the functional significance of endogenous cis-antisense transcripts, which are the transcriptional output from the opposite strand of annotated genes. These transcripts are one of the most common types of transcripts that do not correspond to any protein-coding loci. Historical molecular studies revealed the existence of antisense transcripts associated with dozens of gene loci, whereas more recent genome-wide studies have shown that many genes have an antisense counterpart thus stimulating investigations into the functional significance of endogenous antisense transcripts. Here, we summarize the recent progress in the genome-wide characterization of the antisense transcriptome, and discuss the biological mechanisms that underlie the regulatory machinery of eukaryotic gene expression with respect to the potential roles of endogenous cis-antisense transcripts.

Antisense transcript
Non-coding RNA
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