IMR Press / FBL / Volume 15 / Issue 3 / DOI: 10.2741/3660

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
TRPC channels in smooth muscle cells
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1 The Center for Cardiovascular Sciences, Albany Medical College, Albany, NY, USA
Academic Editor:Guillermo Vazquez
Front. Biosci. (Landmark Ed) 2010, 15(3), 1023–1039; https://doi.org/10.2741/3660
Published: 1 June 2010
Abstract

Transient receptor potential canonical (TRPC) proteins constitute a family of seven (TRPC1-7) nonselective cation channels within the wider TRP superfamily. TRPC1, TRPC3, TRPC4, TRPC5 and TRPC6 channels are expressed in vascular smooth muscle cells from human vessels of all calibers and in smooth muscle from organs such as the uterus and the gastrointestinal tract. TRPC channels have recently emerged as important players in the control of smooth muscle function. This review will focus on the retrospective analysis of studies proposing contributions of TRPC channels to native calcium entry pathways in smooth muscle and to physiological and pathophysiological responses with emphasis on the vascular system.

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