IMR Press / FBL / Volume 15 / Issue 1 / DOI: 10.2741/3625

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
A decade in search of myopia genes
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1 Ambulatory Eye Surgery Center, Siemensstrasse 13, D-35394, Giessen, Germany
2 Institute of Anthropology and Human Genetics, Division of Molecular Genetics, University of Tübingen, Wilhelmstrasse 27, D-72074 Tübingen, Germany
Academic Editor:Giovanni Li Volti
Front. Biosci. (Landmark Ed) 2010, 15(1), 359–372; https://doi.org/10.2741/3625
Published: 1 January 2010
(This article belongs to the Special Issue Biochemical markers in biological fluids)
Abstract

Nearly half of visual impairment in the world is caused by uncorrected refractive errors, and myopia constitutes a significant proportion of this problem. Moreover, the prevalence of myopia is increasing, especially in Asian countries. Linkage studies have identified at least 18 possible loci (MYP) in 15 different chromosomes associated with myopia, although some of these remain to be confirmed. However, when studies have been carried out to identify specific candidate genes, it is apparent that these genes are often not part of MYP loci. In studying the expression of specific genes that might be responsible for myopia, we are learning that the involvement of various small leucine-rich repeat proteoglycans and growth factors is not a simple one. The emerging picture is one of complex interaction, in which mutations in several genes likely act in concert. The majority of myopia cases are not likely caused by defects in structural proteins, but in defects involving the control of structural proteins. The future of genetic research in this area will likely rely increasingly on microchip array technology.

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