IMR Press / FBL / Volume 14 / Issue 9 / DOI: 10.2741/3457

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Imaging of early inflammation in low-to-moderate carotid stenosis by 18-FDG-PET
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1 Department of Neurology, University Hospital of Bellvitge (HUB), Fundacio Idibell, Barcelona, Spain
2 Institut de Diagnostic per la Imatge (IDI), University Hospital of Bellvitge (HUB), Fundacio Idibell , Barcelona, Spain
3 Centro de Investigacion Cardiovascular, CSIC-ICCC, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
4 School of Biology, Chemistry and Health Science, Manchester Metropolitan University, Manchester, United Kingdom
5 Department of Neurology, Hospital Mutua de Terrassa, Terrassa, Spain

Academic Editor: Mark Slevin

Front. Biosci. (Landmark Ed) 2009, 14(9), 3352–3360; https://doi.org/10.2741/3457
Published: 1 January 2009
Abstract

It is not clear if 18FDG-PET can be useful for detection of inflammation in low to moderate carotid stenosis. We studied 15 patients scheduled for endarterectomy with contralateral carotids with less than 50% stenosis. 18-FDG-PET was performed prior to CEA and 3 months following surgery. FDG-uptake values were calculated based on maximum standardized uptake value (SUV) and corresponding uptake ratios. We confirmed by CD68 macrophage staining that FDG accumulation corresponds to active inflammation (R=0.8 p<0.005). We found significant correlation between the FDG-uptake in the carotids scheduled for CEA and contralateral carotids with low to moderate stenosis (R=0.9 p<0.001). The FDG uptake ratio in the contralateral arteries remained stable on the follow-up imaging (1.15+/-0.2 vs. 1.14+/-0.1; R=0.7 p=0.006). We did not find correlation between FDG uptake and symptomatic or asymptomatic patients, degree of carotid stenosis and vascular risk factors. This is a prospective, preliminary in vivo study demonstrating that low to moderate carotid atherosclerosis can be detected using 18-FDG-PET imaging and highlights the truly systemic nature of atherosclerosis.

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