IMR Press / FBL / Volume 14 / Issue 6 / DOI: 10.2741/3384

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Regulation of neutrophil apoptosis by cytokines, pathogens and environmental stressors
Show Less
1 Institute of Hematologic Research, National Academy of Medicine, Buenos Aires, Argentina
Academic Editor:Andrea Doseff
Front. Biosci. (Landmark Ed) 2009, 14(6), 2372–2385; https://doi.org/10.2741/3384
Published: 1 January 2009
(This article belongs to the Special Issue Mechanisms of survival and cell death in leukocytes)
Abstract

As a key component of the innate immune response, neutrophils play a major role in host protection against bacterial and fungi infections. Neutrophils are short-lived phagocytic cells and, as a first line of defense against host insult, they are rapidly and massively recruited from the circulation into inflammatory sites, where the expression of their apoptotic program can be regulated by a number of agents such as cytokines, pathogens and environmental stressors. Apoptosis of neutrophils is central to homoeostasis and the resolution of inflammation. Recent studies have highlighted the complex convergence of different pathways in the regulation of neutrophil survival. This review focuses on the mechanisms involved in the induction and regulation of neutrophil apoptosis.

Share
Back to top