IMR Press / FBL / Volume 14 / Issue 2 / DOI: 10.2741/3255

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Cystatins and cancer
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1 AT Still University, Department of Biochemistry, Kirksville, Missouri, USA
Academic Editor:James Cox
Front. Biosci. (Landmark Ed) 2009, 14(2), 463–474; https://doi.org/10.2741/3255
Published: 1 January 2009
(This article belongs to the Special Issue Cystatins in health and disease)
Abstract

Cystatins are natural cysteine protease inhibitors which belong to a superfamily of proteins with wide occurrence in tissues. The cystatins have been shown to play multiple roles in normal and disease processes. In many different cancers the cathepsins, enzymes inhibited by cystatins, are elevated and participate in tumor growth and invasion. The levels of the cystatins can vary quite widely in different cancers. Recent studies have shown cystatins can block invasion or metastasis of different cancers in experimental systems. Insights into cystatin roles in cancer have provided links to tumor development, angiogenesis, and tumor cell death in this devastating disease.

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