IMR Press / FBL / Volume 14 / Issue 11 / DOI: 10.2741/3513

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Hazardous environmental factors enhance impairment of liver function in HBV and HCV hepatitis
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1 Department of Environmental Health, University of Occupational and Environmental Health, Kitakyushu, 807-8555, Japan
2 Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, 807-8555, Japan
3 Global COE-MED, Nagoya University School of Medicine, Nagoya, 466-8550, Japan

Academic Editor: Norio Kagawa

Front. Biosci. (Landmark Ed) 2009, 14(11), 4071–4078;
Published: 1 January 2009
(This article belongs to the Special Issue Gene regulation and structure-function of P450 Cold stress response)

Hepatitis B virus (HBV) and hepatitis C virus (HCV) often cause chronic liver disease. We hypothesized that environmental factors adversely impact the liver function in workers with these types of hepatitis. We used liver function tests including aspartate aminotransferase, alanine aminotransferase, and γ-glutamyltransferase to evaluate whether hazardous work conditions increase the incidence of chronic liver disease among HBV and HCV infected workers. Organic solvent, night work, visual display terminals, dust, lead, vibrations, and ionizing radiation all led to increased impairment of liver function in patients with hepatitis as compared to the control group that were not exposed to such agents. Therefore, hazardous working conditions have to be carefully considered in the progress of chronic liver disease in workers infected with HBV and HCV.

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