IMR Press / FBL / Volume 13 / Issue 9 / DOI: 10.2741/2923

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Biochemistry of inositol lipids
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1 National University of Singapore, Yong Loo Lin School of Medicine, Department of Biochemistry, and Department of Biological Sciences, Centre for Life Sciences, 28 Medical Drive, Number 04-26D, Singapore 117456

*Author to whom correspondence should be addressed.

Academic Editor: Xianlin Han

Front. Biosci. (Landmark Ed) 2008, 13(9), 3239–3251;
Published: 1 May 2008
(This article belongs to the Special Issue Lipidomics: developments and applications)

Nature has created an immense combinatorial and structural heterogeneity among lipids. It is becoming increasingly accepted that the vast range of unique chemical entities encodes for distinct functions within biological systems. A unique group of lipids which stands out in terms of diversity as well as biological activity are inositol-containing lipids. The most well characterized inositol lipids are the phosphoinositides, phosphorylated derivatives of glycerophosphoinositol, which play a wide variety of cellular roles in many eukaryotic cells. Less well understood are ceramides containing inositol in fungi, and inositol glycolipids in pathogens. Here we review biochemical aspects of inositol-containing lipids with a focus on novel analytical procedures for their characterization.

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