IMR Press / FBL / Volume 13 / Issue 9 / DOI: 10.2741/2922

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Gingipain-dependent interactions with the host are important for survival of Porphyromonas gingivalis

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1 Department of Biochemistry and Microbiology, School of Medicine, Loma Linda University, Loma Linda, California
2 The Center for Health Disparities and Molecular Medicine, Loma Linda University, Loma Linda, California

*Author to whom correspondence should be addressed.

Academic Editor: George Hajishengallis

Front. Biosci. (Landmark Ed) 2008, 13(9), 3215–3238;
Published: 1 May 2008

Porphyromonas gingivalis, a major periodontal pathogen, must acquire nutrients from host derived substrates, overcome oxidative stress and subvert the immune system. These activities can be coordinated via the gingipains which represent the most significant virulence factor produced by this organism. In the context of our contribution to this field, we will review the current understanding of gingipain biogenesis, glycosylation, and regulation, as well as discuss their role in oxidative stress resistance and apoptosis. We can postulate a model, in which gingipains may be part of the mechanism for P. gingivalis virulence.

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