IMR Press / FBL / Volume 13 / Issue 6 / DOI: 10.2741/2834

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Cell cycle control as a basis for cancer chemoprevention through dietary agents
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1 Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
2 Department of Environmental Health Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
3 Department of Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
4 Department of Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
5 Birmingham Veterans Affairs Medical Center, Birmingham, AL, 35294, USA

*Author to whom correspondence should be addressed.

Academic Editor: Rakesh Srivastava

Front. Biosci. (Landmark Ed) 2008, 13(6), 2191–2202;
Published: 1 January 2008
(This article belongs to the Special Issue Cancer chemoprevention - 2)

The development of cancer is associated with disorders in the regulation of the cell cycle. The purpose of this review is to briefly summarize the known sequence of events that regulate cell cycle progression with an emphasis on the checkpoints and the mechanisms cell employ to insure DNA stability in the face of genotoxic stress. Key transitions in the cell cycle are regulated by the activities of various protein kinase complexes composed of cyclin and cyclin-dependent kinases (CDK) molecules. The cyclins are CDK binding partners which are required for kinase activity and their protein levels are intimately linked to the cell cycle stage. CDK activity can be regulated by other mechanisms, such as phosphorylation events, that may contribute to deregulation of cell cycle and the development of cancer. While fruits and vegetables are recommended for prevention of cancer, their active ingredients and mechanisms of action are less well understood. Here, we briefly present evidence that dietary agents identified from fruits and vegetables can act to modulate the effects of deregulated cell cycle checkpoints, and that this may contribute to the prevention of cancer. The agents include apigenin (celery, parsley), curcumin (turmeric), (-)-epigallocatechin-3-gallate (green tea), resveratrol (red grape, peanuts and berries), genistein (soybean), and silymarin (milk thistle). The teachings of Hippocrates are still true "let food be thy medicine and medicine be thy food".

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