IMR Press / FBL / Volume 13 / Issue 6 / DOI: 10.2741/2821

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
NgR acts as an inhibitor to axonal regeneration in adults
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1 Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing(400016), China
2 Department of Neurosurgery, Loma Linda University School of Medicine, Loma Linda, California, USA
Academic Editor:John Zhang
Front. Biosci. (Landmark Ed) 2008, 13(6), 2030–2040; https://doi.org/10.2741/2821
Published: 1 January 2008
(This article belongs to the Special Issue New frontiers in neurosurgery research)
Abstract

After injury to the central nervous system (CNS) in adults, axonal regeneration is confined, in part, by the inhibitory factors in CNS myelin, including Nogo-A protein, myelin-associated glycoprotein (MAG) and oligodendrocyte myelin glycoprotein (OMGP). These proteins, all bind to the same neuronal glycosylphosphatidylinositol-anchored receptors (NgR), and transduce inhibitory signals to cells by the transmembrane co-receptor, p75. The final outcome of this event is inhibition of axonal regeneration and recovery of locomotion. Based on these findings, one avenue for promotion of axonal regeneration is by virtue of blocking the inhibitory effects of NgR.

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