IMR Press / FBL / Volume 13 / Issue 11 / DOI: 10.2741/2996

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article
The GTPase Ran: regulation of cell life and potential roles in cell transformation
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1 Institute of Molecular Biology and Pathology, CNR National Research Council, c/o Department of Genetics and Molecular Biology, Sapienza University of Rome, via degli Apuli 4, 01185 Rome, Italy

*Author to whom correspondence should be addressed.

 

Front. Biosci. (Landmark Ed) 2008, 13(11), 4097–4121; https://doi.org/10.2741/2996
Published: 1 May 2008
Abstract

The GTPase Ran plays a crucial role in nucleo–cytoplasmic transport of tumor suppressors, proto-oncogenes, signaling molecules and transcription factors. It also plays direct roles in mitosis, through which it regulates faithful chromosome segregation and hence the generation of genetically stable cells. Ran operates through a group of effector proteins. In this review we summarize growing evidence suggesting that deregulated activity of Ran or its effectors can contribute to pathways of cell transformation and facilitate tumor progression.

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