IMR Press / FBL / Volume 12 / Issue 7 / DOI: 10.2741/2252

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Osteoclast differentiation and gene regulation
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1 Life Science College, Zhejiang University, Hongzhou, China
2 Department of Cytokine Biology Forsyth Institute, Boston Massachusetts, USA
3 Department of Oral Biology Harvard School of Dental Medicine Boston Massachusetts, USA
Front. Biosci. (Landmark Ed) 2007, 12(7), 2519–2529;
Published: 1 January 2007

Osteoclasts, the bone resorbing cells, play a key role both in normal bone remodeling and in the skeletal osteopenia of arthritis, osteoporosis, periodontal disease and certain malignancies. Osteoclast cellular commitment, differentiation and function depend upon the establishment of specific patterns of gene expression achieved through networks of transcription factors activated by osteoclastogenic cytokines. This review is an updated look at the various transcription factors and cytokines that have been demonstrated to play critical roles in osteoclast differentiation and function, along with their known animal models, such as: PU.1, Mcsf, RANKL, NF-kappaB, AP-1, NFATc1, Mitf, Myc, and Src. Further studies on these transcription factors and cytokines will not only expand our basic understanding of the molecular mechanisms of osteoclast differentiation, but will also aid our ability to develop therapeutic means of intervention in osteoclast-related diseases.

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