IMR Press / FBL / Volume 11 / Issue 3 / DOI: 10.2741/2028

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Recent advances in melanoma research
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1 Department of Pathology, Baylor College of Medicine, Houston, TX, USA
2 Department of Dermatology, Baylor College of Medicine, Houston, TX, USA
3 Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA
4 Departments of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
Front. Biosci. (Landmark Ed) 2006, 11(3), 3003–3013;
Published: 1 September 2006

At the end of the last decade, sporadic melanomas were still considered a genetic black box. Fortunately, in the last few years the box has been opened bringing to light melanoma-relevant oncogenes, aberrant signal transduction pathways, critical alterations in the melanoma cell cycle that go beyond p16INK4a, and melanoma- microenvironment interactions that are essential for tumor progression. This review will discuss some of the latest findings in melanoma research including the critical role of the MAPK pathway in the genesis of melanoma and senescence of nevi, the paradoxical tumor suppressor and oncogenic activities of the transcription factor MITF, and the unexpected oncogenic activities of the low molecular weight forms of cyclin E.

Cyclin E
HDAC Inhibitors
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