IMR Press / FBL / Volume 11 / Issue 3 / DOI: 10.2741/2019

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Steroid hormone mediated regulation of corticotropin-releasing hormone gene expression
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1 Department of Physiology, Second Military Medical University, Key Laboratory of Molecular Neurobiology, Ministry of Education, Shanghai, P.R. China
2 Mothers and Babies Research Centre, John Hunter Hospital, Newcastle, NSW, Australia
Academic Editor:Richard Nicholson
Front. Biosci. (Landmark Ed) 2006, 11(3), 2909–2917; https://doi.org/10.2741/2019
Published: 1 September 2006
(This article belongs to the Special Issue Corticotrophin releasing hormone)
Abstract

Corticotropin-releasing hormone (CRH), a 41 amino acid polypeptide, is expressed in many regions of central nervous system and peripheral tissues and mediates many physiological functions. Abnormal production of CRH is involved in some pathological processes. Among various endogenous factors that modulate CRH production, steroid hormones control CRH production by regulating its gene transcription. Although there is no classical steroid hormone response element in the CRH promoter, steroid hormones regulate CRH gene expression through protein-protein interaction or by binding directly to response elements.

Keywords
Corticotrophin-releasing hormone
Gene
Transcription
Glucocorticoid
Estrogen
Androgen
Promoter
Review
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