IMR Press / FBL / Volume 11 / Issue 3 / DOI: 10.2741/2016

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Cyclooxygenase 2: understanding the pathophysiological role through genetically altered mouse models
Show Less
1 Centro de Investigaciones Biologicas CIB (CSIC), Melchor Fernandez Almagro 3, 28029 Madrid, Spain
2 Centro Nacional de Investigaciones Cardiovasculares (CNIC). Melchor Fernandez Almagro 3, 28029 Madrid, Spain
3 Instituto de Biomedicina de Valencia (CSIC) Jaime Roig 11, 46010 Valencia, Spain
Academic Editor:Vicente Andres
Front. Biosci. (Landmark Ed) 2006, 11(3), 2876–2888;
Published: 1 September 2006

Cyclooxygenase (COX) -1 and –2 catalyze the first step in the biosynthesis of prostanoids. COX-1 is constitutively expressed in many tissues and seems to be involved in the housekeeping function of prostanoids. COX-2, the inducible isoform, accounts for the elevated production of prostaglandins in response to various inflammatory stimuli, hormones and growth factors. COX-2 expression has been also associated with cell growth regulation, tissue remodelling and carcinogenesis. More of these characteristics have been elucidate through using COX selective inhibitors. Recent advances in transgenic and gene-targeting approaches allow a sophisticated manipulation of the mouse genome by gene addition, gene deletion or gene modifications. The development of COX-2 genetically altered mice has provided models to elucidate the physiological and pathophysiological roles of this enzyme.

Genetically Altered Animal Model
Back to top