IMR Press / FBL / Volume 11 / Issue 3 / DOI: 10.2741/1972

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article
Corticotropin-releasing hormone in nonhuman primates
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1 Department of Psychology, School of Psychology, Psychiatry and Psychological Medicine, Monash University, Victoria 3800, Australia
Front. Biosci. (Landmark Ed) 2006, 11(3), 2303–2335; https://doi.org/10.2741/1972
Published: 1 September 2006
Abstract

Understanding the many roles that corticotropin-releasing hormone (CRH) plays in facilitating the ordinary and extraordinary events that an individual faces during a lifetime is a complex task, and yet this knowledge is fundamental to understanding our own behaviour and physiology. During the past 25 years, the study of CRH in nonhuman primates, our closest genetic relatives, has grown rapidly. The intention of this review is to provide a broad overview of the research areas in which CRH has been investigated in monkeys and apes. The review begins with a detailed description of what we know about CRH, CRH receptors, and their distribution in the brain and periphery. The narrative then follows the life cycle, from the role of CRH in fertility, pregnancy and parturition, to the shaping of behaviour and neural processes by stressful experiences early in life. CRH is also examined in the context of its other regulatory roles, including appetitive behaviour and immune responses. Finally, the review examines the insights that nonhuman primate research offers us as to how CRH helps to shape our behaviour, whether it be our ability to socialize with our peers or to be a good parent.

Keywords
Nonhuman Primate
Monkey
Ape
Corticotropin-Releasing Hormone
Behaviour
Fertility
Parturition
Stress
Endocrinology
Appetite
Cortisol
Glucocorticoids
Adrenocorticotropin
Review
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