IMR Press / FBL / Volume 11 / Issue 3 / DOI: 10.2741/1965

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Real-time contrast-enhanced specific ultrasound in staging and follow-up of splenic lymphomas
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1 Department of Medical Oncology,S. Maria delle Grazie Hospital Pozzuoli, Italy
2 Department of Radiology, National Cancer Institute, Naples, Italy
3 Epidemiology and Population Genetics, Institute of Food Science, Avellino, Italy
4 Department of Radiology, S. Maria delle Grazie Hospital Pozzuoli, Italy
5 Department of Medical Oncology, National Cancer Institute, Naples, Italy
Academic Editor:Antonio Giordano
Front. Biosci. (Landmark Ed) 2006, 11(3), 2224–2229; https://doi.org/10.2741/1965
Published: 1 September 2006
(This article belongs to the Special Issue Gene targets for modulating cell growth)
Abstract

From January 2003 to April 2005 we studied 25 lymphoma patients (10 with HD, 4 with low-grade NHL, 6 with high-grade NHL and 5 with chronic lymphatic leukaemia; 14 men, 11 women, age range 28-79 years). After a baseline US study we rapidly injected 4.8 mL of the second-generation microbubble contrast agent SonoVue (Bracco, Italy). Contrast enhanced studies were carried out with the contrast-specific software named Contrast Tuned Imaging (Esaote, Italy) using a continuous, harmonic acquisition and a low acoustic pressure. The CS-US findings were correlated with results of standard tools, including CT, MRI, US follow up. CS-US revealed correctly 47 out of the 52 lesions identified by CT scan, in the absence of false positive findings (sensitivity = 90%; Specificity = 100%, in comparison to CT scan). Complete concordance in evaluating the lesion extension of the CS-US in respect to CT was 88%, while underestimate occurred in 9% and overestimate in 3% of cases. On the contrary, basic sonography defined correctly the dimensional alteration in 52% of the cases, underestimated in 35% and overestimated in 13%, thus showing significantly lower accuracy (chi-square = 30.0, p < 0.001). In our experience, CS-US was superior to conventional sonography even from a qualitative point of view.

Keywords
Lymphomas
Tumor
Cancer
Lymph node
Contrast-Enhanced Specific Ultrasound
Staging
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