IMR Press / FBL / Volume 11 / Issue 3 / DOI: 10.2741/1963

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Surgical treatment of differentiated thyroid carcinoma: a retrospective study
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1 Department of Anaesthesiological, Surgical and Emergency Sciences, Vth Unit of Surgery and Advanced Surgical Procedures, Second University of Naples, Piazza Miraglia, Naples, Italy
2 Department of Morphopathology Second University of Naples., Italy
3 Nuclear Medicine Second University of Naples, Italy
4 IXth Unit of Biotechnology Applied to Surgery, Second University of Naples, Italy
5 Department of Head and Neck Surgery, Second University of Naples, Italy
6 Department of Head and Neck Surgery, Hospital of Terni, Italy
Academic Editor:Antonio Giordano
Front. Biosci. (Landmark Ed) 2006, 11(3), 2206–2212; https://doi.org/10.2741/1963
Published: 1 September 2006
(This article belongs to the Special Issue Gene targets for modulating cell growth)
Abstract

A retrospective study was carried out to assessed reliability of the prognostic factors (histology, age, sex, and stage), and standard procedures for the surgical treatment of differentiated thyroid cancers (DTC). From the 144 DTC cases reviewed with follow-up ranging from 1 to 25 years (m = 6.33 years), total mortality for cancer was found to be 55% (8 patients), with a predictive positive value for recurrence of 95.4% and 91.8% at 12 and 24 months, respectively. Median survival was 8.8 years (range 1 to 25 years). The multivariate analysis showed that factors such as age > 45 years, histology of intermediate malignancy, size up to 1.5 cm, and presence of metastases, significantly worsened the prognosis, regardless of the intervention that was carried out. We suggest total thyroidectomy for the treatment of benign pathologies and confirmed or suspected cases of cancer. We reserve loboisthmectomy for the treatment of benign pathologies confined to one lobe or those with FNAB suggesting a follicular neoplasm.

Keywords
Differentiated Thyroid Carcinoma
Prognostic Factors In Thyroid Carcinoma
Total Thyroidectomy
Cancer
Tumor
Neoplasia
Treatment
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