IMR Press / FBL / Volume 1 / Issue 4 / DOI: 10.2741/A112

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Soluble Fas/Apo-1 splicing variants and apoptosis
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1 Department of Immunobiology, Institute of Cell Biology, National Research Council, Rome, Italy
Front. Biosci. (Landmark Ed) 1996, 1(4), 12–18;
Published: 1 January 1996

In addition to the full length mRNA activated human peripheral blood mononuclear cells (PBMC) and T cell tumor lines express several alternatively spliced Fas variants. At least five of these code for soluble Fas (CD95) molecules. In vitro studies suggest that these soluble Fas isoforms inhibit apoptosis induced by agonistic antibodies and, more importantly, by the natural Fas ligand in Fas-bearing sensitive cells. Interestingly, this functional property can be assigned to the first 49 aminoacids of the mature protein, the only region shared by the soluble Fas molecules.

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