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[1]A Muhammad, O A Odunola, A D Farooq, A M Mesaik, M I Choudhary, O L Erukainure, S Perveen, A Jabeen: Fractionation of acacia honey affects its antioxidant potential in vitro, J Acute Dis, 1(2), 115–119, (2012)
[2]E Pichichero, R Cicconi, M Mattei, M G Muzi, A Canini: Acacia honey and chrysin reduce proliferation of melanoma cells through alterations in cell cycle progression, Int J of oncol, 973–981, (2010)
[3]M Al-yahya, R Mothana, M Al-said, M Al-dosari, N Al-musayeib, M Al-sohaibani, M K Parvez, S Rafatullah: Attenuation of CCl 4 -Induced Oxidative Stress and Hepatonephrotoxicity by Saudi Sidr Honey in Rats, Evidence-based Complement Altern Med, 2013, 10, (2013)
[4]O O Erejuwa, S A Sulaiman, M S A Wahab: Honey: A Novel Antioxidant, Molecules, 17, 4400–4423, (2012)
[5]R Carnwath, E M Graham, K Reynolds, P J Pollock: The antimicrobial activity of honey against common equine wound bacterial isolates, Vet J, 199(1), 110–114, (2014)
[6]L A Marghitas, D S Dezmirean, C B Pocol, M Ilea, O Bobis, I Gergen: The Development of a Biochemical Profile of Acacia Honey by Identifying Biochemical Determinants of its Quality, Not Bot Horti Agrobot Cluj-Napoca, 38(2), 84–90, 2010
[7]A Muhammad, O A Odunola, S E Owumi, M A Gbadegesin, A D Farooq, H Rasheed, M I Choudhary, O L Erukainure: Daily Consumption of Honey : Effects on Male Wister Albino Rats, Food Nutr Saf, 1(2), 66–74, (2012)
[8]S Gomes, L G Dias, L L Moreira, P Rodrigues, L Estevinho: Physicochemical, microbiological and antimicrobial properties of commercial honeys from Portugal, Food Chem Toxicol, 48(2), 544–548, (2010)
[9]K Ruoff: Authentication of the Botanical Origin of Honey Report, DISS ETH NO 16857, 1-13, (2006)
[10]S Bibi, S Z Husain, R N Malik, S Bibi, E T Al: Pollen Analysis and Heavy Metals Detection in Honey Samples from Seven Selected Countries, Pak J Bot, 40(2), 507–516, (2008)
[11]O Adekanmbi, O Ogundipe: Nectar sources for the honey bee (Apis mellifera adansonii) revealed by pollen content, Not Bot Horti Agrobot Cluj-Napoca, 37, 211–217, (2009)
[12]P M Lutier, B E Vaissière: An improved method for pollen analysis of honey, Rev of Pal and Paly, 78 129–144, (1993)
[13]N T Moar: Pollen analysis of New Zealand honey, New Zealand J of Agric Res, 28 39–70, (1985)
[14]A Muhammad, OA Odunola, AD Farooq, H Rasheed, AM Mesaik, M I Choudhary, I S Channa, S A Khan, OL Erukainure: Molecular Mechanism of Antiproliferation Potential of Acacia Honey on NCI-H460 Cell Line, Nutr and Cancer, 65 2, 296-304, (2013)
[15]O A Odunola, A Muhammad, A D Farooq, K Dalvandi, H Rasheed, M I Choudhary, L Erukainure: Comparative assessment of redox-sensitive biomarkers due to acacia honey and sodium arsenite administration in vivo, Mediterr J Nutr Metab, 6(2), 119–126, (2013)
[16]A Cristina, S Jesús, I MartÍnez-castro: SPME followed by GC – MS : a powerful technique for qualitative analysis of honey atiles, Eur Food Res Technol 228, 579–590, (2009)
[17]S Qamer, M Ehsan, S Nadeem, A R Shakoori: Free Amino Acids Content of Pakistani Unifloral Honey Produced by Apis mellifera, Pak J Zool, 39(2), 99–102, (2007)
[18]T O N Y W Oodcock, G E D Owney, J D A K Elly, C O L M O D Onnell: Geographical Classification of Honey Samples by Near-Infrared Spectroscopy : A Feasibility Study, J Agric Food Chem, 55, 9128–9134, (2007)
[19]S Bibi, S Z Husain, R N Malik: Pollen analysis and heavy metals detection in honey samples from seven selected countries, Pakistan J Bot, 40, 507–516, (2008)
[20]J Miguel, A S Tulipani, S Romandini, E Bertoli, M Battino: Contribution of honey in nutrition and human health : a review, Med J Nutrition Metab, 3, 15–23, (2010)
[21]A Muhammad, O A Odunola, A D Farooq, A M Mesaik, I Muhammad, M Azhar, M M Asif, O L Erukainure: Antioxidant, mitogenic and immunomodulatory potentials of acacia honey, Nutr Ther Met, 32(2), 68–78, (2014)
[22]D Koshland, A Strunnikov: Mitotic chromosome condensation Annu Rev Cell Dev Biol, 12, 305–333, (1996)
[23]H Lis, N Sharon: Lectins: Carbohydrate-Specific Proteins That Mediate Cellular Recognition, Chem Rev, 98, 637–674, (1998)
[24]A Öcal, H E Eroğlu: in vitro cytogenetic effects of Hypericum heterophyllum in human peripheral blood lymphocytes, J Bangaladesh Pharmacol Soc, 7, 36–41, (2012)
[25]S K Jaganathan, M Mandal: Antiproliferative Effects of Honey and of Its Polyphenols : A Review Chemistry of Honey, J Biomed Biotechnol, 2009, 13, (2009)
[26]S E Owumi, O A Odunola, M Aliyu: Co-administration of sodium arsenite and ethanol: Protection by aqueous extract of Aframomum longiscapum seeds, Pharmacognosy Res, 4(3), 154–60, (2012)
[27]R Lotan: Retinoids in cancer chemoprevention, FASEB J, 10(9), 1031–1039, (1996)
[28]A Muhammad, O A Odunola, A D Farooq, A M Mesaik, M I Choudhary, B Fatima, T A Qureshi: Acacia Honey Modulates Cell Cycle Progression, Pro-inflammatory Cytokines and Calcium Ions Secretion in PC-3 Cell Lines, cancer Sci Ther, 4(12), 401–407, (2012)
[29]M M Rahman, S H Gan, I Khalil: Neurological Effects of Honey : Current and Future Prospects, Evidence-based Complement Altern Med, 2014, 13, (2014)
[30]A Muhammad, O A Odunola, M A Gbadegesin, A B Sallau, U S Ndidi, M A Ibrahim: Inhibitory Effects of Sodium Arsenite and Acacia Honey on Acetylcholinesterase in Rats, Int J Alzheimer’s Dis, 2015, 7, (2015)
[31]T D Shear, J A J Martyn: Physiology and biology of neuromuscular transmission in health and disease, J Crit Care, 24, 5–10, (2009)
[32]S Samat, N A M Nor, F Nor Hussein, W I W Ismail: Effects of Gelam and Acacia honey acute administration on some biochemical parameters of Sprague Dawley rats, BMC Complement Altern Med, 14, 1, 146, (2014)
[33]F Iftikhar, M Arshad, F Rasheed, D Amraiz, P Anwar, M Gulfraz: Effects of Acacia Honey on Wound Healing in Various Rat Models Phyther Res, 24, 583–586, (2010)
[34]C Ker-Woon, N Abd Ghafar, C Kien Hui, Y A Mohd Yusof: Effect of acacia honey on cultured rabbit corneal keratocytes, BMC Cell Biol, 15 (1)19, (2014)
[35]A Muhammad, OA Odunola, MA Gbadegesin, AM Adegoke, JO Olugbami, NS Uche: Modulatory role of Acacia honey from north-west Nigeria on sodium arsenite-induced clastogenicity and oxidative stress in male Wistar rats, Nat Prod Res 29 (4), 321-326, (2014)
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Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
Potential biological activity of acacia honey
, Oyeronke A. Odunola 2, Mohammed A. Ibrahim 1, Abdullahi B. Sallau 1, Ochuko L. Erukainure 3, Idowu A. Aimola 1, Ibrahim Malami 41 Department of Biochemistry, Ahmadu Bello University, Zaria, Kaduna State, Nigeria
2 Cancer Research and Molecular Biology Laboratories, Department of Biochemistry, University of Ibadan, Ibadan, Oyo State, Nigeria
3 Department of Food Technology, Federal Institute of Industrial Research, Oshodi, Nigeria
4 Department of Pharmacognosy and Ethnopharmacy, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto
*Author to whom correspondence should be addressed.
Abstract
Recent advances in functional foods-based research have increasingly become an area of major interest because it affects human health and activities. Functional foods are classes of foods with health promoting and disease preventing properties in addition to multiple nutritional values and of such type is honey. Acacia honey is a type of honey produced by bees (Apis mellifera) fed on Acacia flowers, hence the name. This review focuses on the potential biological activities of Acacia honey which includes quality, antioxidant, immuno-modulatory, antiproliferative and neurological properties at in vitro and in vivo levels. Based on our review, Acacia honey used from various researches is of high purity, contains some bioactive compounds ranging from vitamins, phenolics, flavonoids and fatty acids. It’s highly nutritional with strong antioxidant and immuno-modulatory potentials which may therefore be considered a potential candidate for both cancer prevention and treatment. Neurologically, it may be considered as a viable therapeutic agent in the management of Alzheimer’s disease.
Keywords
- Acacia honey
- Potentials
- in vitro
- in vivo
- Review
References
- [1] A Muhammad, O A Odunola, A D Farooq, A M Mesaik, M I Choudhary, O L Erukainure, S Perveen, A Jabeen: Fractionation of acacia honey affects its antioxidant potential in vitro, J Acute Dis, 1(2), 115–119, (2012)
- [2] E Pichichero, R Cicconi, M Mattei, M G Muzi, A Canini: Acacia honey and chrysin reduce proliferation of melanoma cells through alterations in cell cycle progression, Int J of oncol, 973–981, (2010)
- [3] M Al-yahya, R Mothana, M Al-said, M Al-dosari, N Al-musayeib, M Al-sohaibani, M K Parvez, S Rafatullah: Attenuation of CCl 4 -Induced Oxidative Stress and Hepatonephrotoxicity by Saudi Sidr Honey in Rats, Evidence-based Complement Altern Med, 2013, 10, (2013)
- [4] O O Erejuwa, S A Sulaiman, M S A Wahab: Honey: A Novel Antioxidant, Molecules, 17, 4400–4423, (2012)
- [5] R Carnwath, E M Graham, K Reynolds, P J Pollock: The antimicrobial activity of honey against common equine wound bacterial isolates, Vet J, 199(1), 110–114, (2014)
- [6] L A Marghitas, D S Dezmirean, C B Pocol, M Ilea, O Bobis, I Gergen: The Development of a Biochemical Profile of Acacia Honey by Identifying Biochemical Determinants of its Quality, Not Bot Horti Agrobot Cluj-Napoca, 38(2), 84–90, 2010
- [7] A Muhammad, O A Odunola, S E Owumi, M A Gbadegesin, A D Farooq, H Rasheed, M I Choudhary, O L Erukainure: Daily Consumption of Honey : Effects on Male Wister Albino Rats, Food Nutr Saf, 1(2), 66–74, (2012)
- [8] S Gomes, L G Dias, L L Moreira, P Rodrigues, L Estevinho: Physicochemical, microbiological and antimicrobial properties of commercial honeys from Portugal, Food Chem Toxicol, 48(2), 544–548, (2010)
- [9] K Ruoff: Authentication of the Botanical Origin of Honey Report, DISS ETH NO 16857, 1-13, (2006)
- [10] S Bibi, S Z Husain, R N Malik, S Bibi, E T Al: Pollen Analysis and Heavy Metals Detection in Honey Samples from Seven Selected Countries, Pak J Bot, 40(2), 507–516, (2008)
- [11] O Adekanmbi, O Ogundipe: Nectar sources for the honey bee (Apis mellifera adansonii) revealed by pollen content, Not Bot Horti Agrobot Cluj-Napoca, 37, 211–217, (2009)
- [12] P M Lutier, B E Vaissière: An improved method for pollen analysis of honey, Rev of Pal and Paly, 78 129–144, (1993)
- [13] N T Moar: Pollen analysis of New Zealand honey, New Zealand J of Agric Res, 28 39–70, (1985)
- [14] A Muhammad, OA Odunola, AD Farooq, H Rasheed, AM Mesaik, M I Choudhary, I S Channa, S A Khan, OL Erukainure: Molecular Mechanism of Antiproliferation Potential of Acacia Honey on NCI-H460 Cell Line, Nutr and Cancer, 65 2, 296-304, (2013)
- [15] O A Odunola, A Muhammad, A D Farooq, K Dalvandi, H Rasheed, M I Choudhary, L Erukainure: Comparative assessment of redox-sensitive biomarkers due to acacia honey and sodium arsenite administration in vivo, Mediterr J Nutr Metab, 6(2), 119–126, (2013)
- [16] A Cristina, S Jesús, I MartÍnez-castro: SPME followed by GC – MS : a powerful technique for qualitative analysis of honey atiles, Eur Food Res Technol 228, 579–590, (2009)
- [17] S Qamer, M Ehsan, S Nadeem, A R Shakoori: Free Amino Acids Content of Pakistani Unifloral Honey Produced by Apis mellifera, Pak J Zool, 39(2), 99–102, (2007)
- [18] T O N Y W Oodcock, G E D Owney, J D A K Elly, C O L M O D Onnell: Geographical Classification of Honey Samples by Near-Infrared Spectroscopy : A Feasibility Study, J Agric Food Chem, 55, 9128–9134, (2007)
- [19] S Bibi, S Z Husain, R N Malik: Pollen analysis and heavy metals detection in honey samples from seven selected countries, Pakistan J Bot, 40, 507–516, (2008)
- [20] J Miguel, A S Tulipani, S Romandini, E Bertoli, M Battino: Contribution of honey in nutrition and human health : a review, Med J Nutrition Metab, 3, 15–23, (2010)
- [21] A Muhammad, O A Odunola, A D Farooq, A M Mesaik, I Muhammad, M Azhar, M M Asif, O L Erukainure: Antioxidant, mitogenic and immunomodulatory potentials of acacia honey, Nutr Ther Met, 32(2), 68–78, (2014)
- [22] D Koshland, A Strunnikov: Mitotic chromosome condensation Annu Rev Cell Dev Biol, 12, 305–333, (1996)
- [23] H Lis, N Sharon: Lectins: Carbohydrate-Specific Proteins That Mediate Cellular Recognition, Chem Rev, 98, 637–674, (1998)
- [24] A Öcal, H E Eroğlu: in vitro cytogenetic effects of Hypericum heterophyllum in human peripheral blood lymphocytes, J Bangaladesh Pharmacol Soc, 7, 36–41, (2012)
- [25] S K Jaganathan, M Mandal: Antiproliferative Effects of Honey and of Its Polyphenols : A Review Chemistry of Honey, J Biomed Biotechnol, 2009, 13, (2009)
- [26] S E Owumi, O A Odunola, M Aliyu: Co-administration of sodium arsenite and ethanol: Protection by aqueous extract of Aframomum longiscapum seeds, Pharmacognosy Res, 4(3), 154–60, (2012)
- [27] R Lotan: Retinoids in cancer chemoprevention, FASEB J, 10(9), 1031–1039, (1996)
- [28] A Muhammad, O A Odunola, A D Farooq, A M Mesaik, M I Choudhary, B Fatima, T A Qureshi: Acacia Honey Modulates Cell Cycle Progression, Pro-inflammatory Cytokines and Calcium Ions Secretion in PC-3 Cell Lines, cancer Sci Ther, 4(12), 401–407, (2012)
- [29] M M Rahman, S H Gan, I Khalil: Neurological Effects of Honey : Current and Future Prospects, Evidence-based Complement Altern Med, 2014, 13, (2014)
- [30] A Muhammad, O A Odunola, M A Gbadegesin, A B Sallau, U S Ndidi, M A Ibrahim: Inhibitory Effects of Sodium Arsenite and Acacia Honey on Acetylcholinesterase in Rats, Int J Alzheimer’s Dis, 2015, 7, (2015)
- [31] T D Shear, J A J Martyn: Physiology and biology of neuromuscular transmission in health and disease, J Crit Care, 24, 5–10, (2009)
- [32] S Samat, N A M Nor, F Nor Hussein, W I W Ismail: Effects of Gelam and Acacia honey acute administration on some biochemical parameters of Sprague Dawley rats, BMC Complement Altern Med, 14, 1, 146, (2014)
- [33] F Iftikhar, M Arshad, F Rasheed, D Amraiz, P Anwar, M Gulfraz: Effects of Acacia Honey on Wound Healing in Various Rat Models Phyther Res, 24, 583–586, (2010)
- [34] C Ker-Woon, N Abd Ghafar, C Kien Hui, Y A Mohd Yusof: Effect of acacia honey on cultured rabbit corneal keratocytes, BMC Cell Biol, 15 (1)19, (2014)
- [35] A Muhammad, OA Odunola, MA Gbadegesin, AM Adegoke, JO Olugbami, NS Uche: Modulatory role of Acacia honey from north-west Nigeria on sodium arsenite-induced clastogenicity and oxidative stress in male Wistar rats, Nat Prod Res 29 (4), 321-326, (2014)