IMR Press / FBE / Volume 4 / Issue 8 / DOI: 10.2741/E589

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Stem cell theory for the pathogenesis of endometriosis

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1 Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan

*Author to whom correspondence should be addressed.

Academic Editor: Khaleque Newaz Khan

Front. Biosci. (Elite Ed) 2012, 4(8), 2754–2763; https://doi.org/10.2741/E589
Published: 1 June 2012
(This article belongs to the Special Issue Frontiers in endometriosis)
Abstract

Proposed hypothetical causes of endometriosis include retrograde menstruation, lymphatic and vascular metastasis, iatrogenic direct implantation, coelomic metaplasia, embryonic rest, and mesenchymal cell differentiation (induction). Each theory, individually, fails to account for all types of endometriotic lesions, thereby implicating combined and/or type-specific mechanisms. Recent evidence supports the presence of endometrial stem/progenitor cells and their possible involvement in eutopic endometrial regeneration and differentiation. Thus an additional novel mechanism for the origin of endometriotic lesions is that they arise from ectopic endometrial stem/progenitor cells.

Keywords
Endometriosis
Endometrium
Stem
Progenitor Cells
Pathogenesis
Implantation
Metaplasia
Bone Marrow
Regeneration
Endothelial Progenitor Cells
Endothelial Cells
Review
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