IMR Press / FBE / Volume 3 / Issue 2 / DOI: 10.2741/E279

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Endocrine disruptors, environmental oxygen, epigenetics and pregnancy
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1 Division of Reproductive Endocrinology and Infertility, Women and Infants Hospital of Rhode Island, Providence, RI
2 Departments of Pathology and Laboratory Medicine and Community Health, Brown University, Providence, RI
3 Department of Pediatrics, Women and Infants Hospital of Rhode Island, Providence, RI

*Author to whom correspondence should be addressed.


Front. Biosci. (Elite Ed) 2011, 3(2), 690–700;
Published: 1 January 2011

The placenta and its myriad functions are central to successful reproductive outcomes. These functions can be influenced by the environment encountered throughout pregnancy, thereby altering the appropriate genetic programming needed to allow for sustained pregnancy and appropriate fetal development. This altered programming may result from epigenetic alterations related to environmental exposures. Epigenetic alterations are now being linked to several important reproductive outcomes, including early pregnancy loss, intrauterine growth restriction, congenital syndromes, preterm birth, and preeclampsia. The diversity of environmental exposures linked to adverse reproductive effects continues to grow. Much attention has focused on the role of endocrine disruptors in infertility, but recent work suggests that these chemicals may also have adverse effects in pregnancy and development. Environmental oxygen is also critical in pregnancy success. There are clear links between altered oxygen levels and placentation amongst other effects. As research continues to enhance our understanding of the molecular processes including epigenetic regulation that influence pregnancy, it will be critical to specifically examine how the environment, broadly defined, may play a role in altering these critical functions.

Endocrine Disruptors
Environmental Oxygen
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