IMR Press / FBE / Volume 13 / Issue 1 / DOI: 10.2741/871

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Animal models for research on endometriosis
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1 Department of Obstetrics and Gynecology, Tottori University Faculty of Medicine, Yonago, 683-8504, Japan
Front. Biosci. (Elite Ed) 2021, 13(1), 37–53; https://doi.org/10.2741/871
Published: 1 October 2020
(This article belongs to the Special Issue Frontiers in endometriosis)
Abstract

Endometriosis results from the aberrant growth of endometrium outside the inner lining of the uterine cavity. Similar to humans, the primates also menstruate and hence, the primate models constitute the gold standard for studying the pathogenesis and potential treatment for this disabling disease in women. Due to the expense in carrying endometriosis research in primates, other models have been developed for understanding the pathobiology and potential treatment of endometriosis. This includes explanting human endometrial tissues in athymic nude mice or using homologous mouse models. Here, we examine the murine models of endometriosis, the impact of forced induced inflammation on its development, similarities in the gene expression profile in the endometriotic tissues in such models with that seen in human endometriosis, and the drugs that are being used in such models as potential new treatment for endometriosis

Keywords
Endometriosis
Murine Endometriosis-Like Lesion
Experimental Model
Cystic Lesion
Review
Figures
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