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IMR Press / CEOG / Volume 49 / Issue 10 / DOI: 10.31083/j.ceog4910222
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Open Access Original Research
Preoperative Evaluation of 3D-MRI on the Depth of Myometrial Invasion of Endometrial Carcinoma: 3D Study of Endometrial Carcinoma
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1 Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, 510515 Guangzhou, Guangdong, China
2 Department of Radiology, Nanfang Hospital, Southern Medical University, 510515 Guangzhou, Guangdong, China
*Correspondence: ccl1@smu.edu.cn (Chunlin Chen); lp2@smu.edu.cn (Ping Liu)
Clin. Exp. Obstet. Gynecol. 2022, 49(10), 222; https://doi.org/10.31083/j.ceog4910222
Submitted: 8 April 2022 | Revised: 13 June 2022 | Accepted: 20 June 2022 | Published: 21 September 2022
(This article belongs to the Special Issue Diagnosis and Treatment of Endometrial Cancer)
This is an open access article under the CC BY 4.0 license.
Abstract

Background: To evaluate the preoperative diagnostic efficacy of 3D-MRI for the depth of myometrial invasion of endometrial carcinoma. Methods: A total of 116 patients with endometrial carcinoma who had undergone pelvic MRI before surgery were included. Mimics 21.0 (Materialize Co., Belgium) software was used to reconstruct three-dimensional MRI models (3D-MRI). The tumor volume and surface area, uterine volume and surface area were measured, and the tumor volume ratio was calculated. TVR (Tumor Volume Ratio) = tumor volume/uterine volume, TAR (Tumor Area Ratio) = tumor surface area/uterine surface area. Postoperative pathology was used as the gold standard to compare the accuracy, sensitivity, specificity, negative predictive value, and positive predictive value of conventional MRI and 3D-MRI in preoperative assessment of endometrial carcinoma myometrial invasion. Results: The accuracy and specificity of 3D-MRI in the diagnosis of deep myometrial invasion were better than conventional MRI (p $<$ 0.05). There was no statistically significant difference in tumor volume or surface area between stage IA and stage IB (p $>$ 0.05), while TVR and TAR showed significant statistical differences (8.05 $\pm$ 0.66 vs. 19.12 $\pm$ 3.20, p $<$ 0.01; 21.38 $\pm$ 1.04 vs. 35.15 $\pm$ 3.42, p $<$ 0.01). Further analysis, the area under the ROC curve of TVR is 0.738, p $<$ 0.01, and the best cut-off value is 13.59%; the area under the ROC curve of TAR is 0.770, p $<$ 0.01, and the best cut-off value is 27.41%. Conclusions: Preoperative 3D-MRI can effectively assess the myometrial invasion of endometrial carcinoma.

Keywords
endometrial carcinoma
3D-MRI
preoperative
tumor volume
tumor surface
Figures
Fig. 1.
Funding
81571422/ The National Natural Science Foundation of China
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