Dear Colleagues,

Inflammation is a fundamental immunological process aimed at restoring homeostasis, however, chronic low-grade inflammation can be destructive. The pathophysiological mechanisms of many diseases, including mental disorders, are linked to inflammation. Changes in peripheral inflammatory markers and signs of neuroinflammation, including microglial activation, brain parenchyma infiltration by immune cells, and blood-brain barrier disruption, have been identified in several psychiatric disorders. Dysregulation of the hypothalamic-pituitary-adrenal axis, the gut-brain axis, and disturbances in the kynurenine pathway are considered the main molecular mechanisms linking peripheral and central inflammation. However, despite advances in understanding inflammatory mechanisms in mental disorders, gaps in knowledge remain.

This special issue of Alpha Psychiatry welcomes original studies, literature reviews, and meta-analyses on inflammatory and immune mechanisms associated with the pathogenesis of major mental disorders, including schizophrenia spectrum disorders, depressive disorders, bipolar disorder, eating disorders, anxiety and post-traumatic stress disorders, and substance use disorders. Research into how anti-inflammatory medications affect psychotic symptoms or how antipsychotics, antidepressants, and other substances affect the immune system in mental disorders is also encouraged.

We look forward to your contributions!

Dr. Evgeny A. Ermakov and Prof. Dr. Svetlana A. Ivanova
Guest Editors