Currently there is a great demand of finding health food resources in the world. ­Presently, large quantities of pumpkin leaves are underutilized. Their potential of being exploited as a health food resource was therefore evaluated in this study. The experimental results indicated that pumpkin leaves were rich in proteins, all essential amino acids, most vitamins (including B₁, B₂, B₃, B₅, B₆, B₁₁, C, A, E and K) and most essential mineral nutrients (including K, Na, P, Ca, Mg, Fe, Zn and Cu) and that they contained significant amount of other functional compounds including polyphenols, alkaloids, saponins and phytates which contributed significantly to the antioxidative capacity of pumpkin leaf extract. A diet with over 90 % source of dietary proteins attributed to pumpkin leaves can be safely consumed throughout lifetime. Comparing with the growth curve of mice fed on a conventional diet, that of mice tested on the pumpkin leaf diet was identical, but their lifespan was significantly longer. Pumpkin leaf powder was therefore concluded to be nutritious and safe for consumption and rich in some other components beneficial to health. These illustrated the potentiality of pumpkin leaves as a valuable health food resource.