IMR Press / FBS / Volume 8 / Issue 2 / DOI: 10.2741/S467

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Potential benefits of colostrum in gastrointestinal diseases

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1 Department of Veterinary Medicine, University of Perugia, via S. Costanzo 4, Perugia, Italy
2 Department of Pharmaceutical Sciences, University of Perugia, Via S. Costanzo, Perugia, Italy
3 Euro-Mediterranean Institute of Science and Technology (IEMEST), Via E. Amari 123, Palermo, Italy
4 DICHIRONS Department, University of Palermo, Via L. Giuffre 5, Palermo, Italy

*Author to whom correspondence should be addressed.

Academic Editor: Munis Dundar

Front. Biosci. (Schol Ed) 2016, 8(2), 331–351;
Published: 1 June 2016
(This article belongs to the Special Issue Genes and genetics)

This paper reviews the composition of colostrum and the potential preventive and therapeutic use of this “first milk” for treating various gastrointestinal disorders in humans. Colostrum is a complex biological liquid that is richer in antimicrobial peptides, immune-regulating compounds and growth factors than the subsequent mature milk. The main functions of colostrum are to provide essential nutritional components, strengthen the natural defense system, modulate immune response, balance intestinal microbiota and enhance the growth and repair of several tissues. Several studies and clinical trials carried out both in vitro and in vivo on humans and animals suggest the clinical benefits of bovine colostrum (BC) supplementation in gastro-intestinal diseases. Despite the encouraging results, further well-designed studies are required in order to confirm these effects, the dose and duration of treatment. Colostrum is safe since there are no contraindications regarding high dose levels and few side effects of clinical relevance have been reported. In conclusion, in the near future, colostrum-based supplements may play a complementary role to synthetic drugs in the prevention and treatment of various gastrointestinal disorders.

Anti-Microbical Factors
Growth Factors
Intestinal Disorders
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