Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
Chemical immobilization of antimicrobial peptides on biomaterial surfaces
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Academic Editor: Octavio Luiz Franco
Hospital infections associated with surgical procedures and implants still present a severe problem in modern societies. Therefore, new strategies to combat bacterial infections mainly caused by microorganisms resistant to conventional antibiotics are necessary. In this context, antimicrobial peptides have gained prominence due to their biocompatibility, low toxicity and effectiveness. The immobilization of antimicrobial peptides (AMPs) onto biomaterial surfaces is an excellent alternative for the development of new biodevices with microbicidal properties. Herein, we describe reports related to physical-chemical characterization, in vitro/in vivo studies and the clinical applicability of such active surfaces. In this review, we focused on the mechanisms of action, different peptide immobilization strategies on solid surfaces and the microbicidal effectiveness of AMPs.