IMR Press / FBS / Volume 4 / Issue 3 / DOI: 10.2741/S306

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

The regulation and activity of interleukin-12
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1 Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA
2 Leukemia Diagnosis and Treatment Center, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin, China
3 Emory College of Arts and Sciences, Emory University, Atlanta, GA

*Author to whom correspondence should be addressed.

Academic Editor: Edmund K. Waller

Front. Biosci. (Schol Ed) 2012, 4(3), 888–899;
Published: 1 January 2012
(This article belongs to the Special Issue New insights in immunology)

Interleukin-12 (IL-12) is a key cytokine in the development of T helper type 1 (Th1) cell polarization, and its production of IL-12 is redundantly regulated. An important pro-inflammatory cytokine, IL-12 has been shown to have potent immunomodulatory, antitumor, and anti-infection activity in vitro and in vivo. Therefore, following a series of promising results from preclinical animal models experiments, researchers have begun to explore the clinical use of recombinant human IL-12 (rhIL-12) for treating a variety of diseases. In a series of phase I and phase II clinical trials related to cancer, viral infections, and hematopoietic stem cell transplants (HSCT), various strategies of rhIL-12 administration have been used with promising preliminary clinical results associated with tolerable toxicities.

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