IMR Press / FBS / Volume 3 / Issue 3 / DOI: 10.2741/208

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Bone phenotypes of P2 receptor knockout mice
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1 Department of Cell and Developmental Biology, University College London, UK
2 Research Center of Ageing and Osteoporosis, Department of Medicine, Copenhagen University Hospital Glostrup, Denmark
3 Mellanby Centre for Bone Research, The University of Sheffield, UK
4 Institute of Interdisciplinary Research (IRIBHM), School of Medicine, Free University of Brussels (ULB), Belgium

*Author to whom correspondence should be addressed.


Front. Biosci. (Schol Ed) 2011, 3(3), 1038–1046;
Published: 1 June 2011

The action of extracellular nucleotides is mediated by ionotropic P2X receptors and G-protein coupled P2Y receptors. The human genome contains 7 P2X and 8 P2Y receptor genes. Knockout mice strains are available for most of them. As their phenotypic analysis is progressing, bone abnormalities have been observed in an impressive number of these mice: distinct abnormalities in P2X7-/- mice, depending on the gene targeting construct and the genetic background, decreased bone mass in P2Y1-/- mice, increased bone mass in P2Y2-/- mice, decreased bone resorption in P2Y6-/- mice, decreased bone formation and bone resorption in P2Y13-/- mice. These findings demonstrate the unexpected importance of extracellular nucleotide signalling in the regulation of bone metabolism via multiple P2 receptors and distinct mechanisms involving both osteoblasts and osteoclasts.

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