IMR Press / FBL / Volume 7 / Issue 4 / DOI: 10.2741/A772

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Bax and BH3-domain-only proteins in p53-mediated apoptosis
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1 Huffington Center on Aging and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Academic Editor:Xiangwei Wu
Front. Biosci. (Landmark Ed) 2002, 7(4), 151–156;
Published: 1 January 2002
(This article belongs to the Special Issue p53 and apoptosis)

Activation of mitochondria-mediated apoptosis represents a major anti-tumor response of p53. One of the mechanisms for p53 to induce mitochondria-mediated cell death events is to activate genes that are directly involved in the initiation of mitochondria-induced apoptosis. Among them are Bcl-2 family members, Noxa, PUMA, and Bax. They have been shown to be direct targets in p53-mediated apoptosis. The Bax protein belongs to the multidomain Bcl-2 family, while Noxa and PUMA are BH3-domain-only proteins. This review focuses on discussing the function of these protein in p53-mediated apoptosis and how they contribute to the decision making of p53 response: growth arrest or apoptosis.

BH3 domain-only proteins
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