IMR Press / FBL / Volume 24 / Issue 3 / DOI: 10.2741/4736

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Modafinil and orexin system: interactions and medico-legal considerations

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1 Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy
2 Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy
3 Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy
4 Complex Structure of Neuropsychiatry Childhood-Adolescence of Ospedali Riuniti of Foggia, Foggia, Italy
5 Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy
6 Anatomy Department, Faculty of Medicine and Surgery, University of Malta, Msida, Malta
7 Clinic of Child and Adolescent Neuropsychiatry, Department of Mental Health, Physical and Preventive Medicine, Università degli Studi della Campania,Luigi Vanvitelli, Naples, Italy

*Author to whom correspondence should be addressed.

Front. Biosci. (Landmark Ed) 2019, 24(3), 564–575;
Published: 1 January 2019
(This article belongs to the Special Issue Biochemical markers in biological fluids)

Modafinil (Mo) is increasingly being used as an enhancement drug rather than for its therapeutic effects. The effects of this drug have been examined in attention deficit disorders, depression, mental fatigue, and in enhancing concentration. The drug possesses wakefulness-promoting properties which are mediated through the interaction of orexinergic system with the activated sympathetic nervous system. Mo exerts a synergistic effect on the orexin system, controls energy expenditure and strengthens the ability of the individual to exercise. Some view Mo as a drug that enhances sports performance, since it induces a prolonged wakefulness and decreasing the sense of fatigue. These characteristics being similar to conventional stimulants have allowed Mo to emerge as a novel stimulant requiring medico-legal considerations. However, more studies are needed to better understand the mid and long-term effects of the drug on user/abuser.

Cognitive Functions
Enhancement Drugs
Mental Fatigue
Orexin System
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