IMR Press / FBL / Volume 10 / Issue 3 / DOI: 10.2741/1764

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Transglutaminase and diseases of the central nervous system
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1 UPR 2228 CNRS, Institut Interdisciplinaire des Sciences du Vivant, Université René Descartes, 45, rue des Saints-Pères, 75270 Paris Cedex 06, France
2 Laboratoire des Mécanismes Réactionnels, CNRS, Ecole Polytechnique, 91128 Palaiseau, France

Academic Editor: Alexey Belkin

Front. Biosci. (Landmark Ed) 2005, 10(3), 3078–3092; https://doi.org/10.2741/1764
Published: 1 September 2005
(This article belongs to the Special Issue Cellular functions of tissue transglutaminase)
Abstract

Alzheimer's disease, Parkinson's disease and diseases of expanded polyglutamine are associated with insoluble protein aggregates and neuronal death. A role for transglutaminase in the stabilization of these aggregates has been proposed. Diseases of polyglutamine expansion have been the most thoroughly investigated and a large body of studies supports the causative role of transglutaminase in aggregation of expanded polyglutamine. However none of the evidence is conclusive. Indisputable evidence of cross-linking by transglutaminase will be required in order to provide firm support for therapeutic measures based on the role of transglutaminase.

Keywords
Enzyme
Transglutaminase
Polyglutamine
Huntington's disease
Alzheimer's disease
Parkinson
aggregates
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