Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
1 UPR 2228 CNRS, Institut Interdisciplinaire des Sciences du Vivant, Université René Descartes, 45, rue des Saints-Pères, 75270 Paris Cedex 06, France
2 Laboratoire des Mécanismes Réactionnels, CNRS, Ecole Polytechnique, 91128 Palaiseau, France
Abstract
Alzheimer's disease, Parkinson's disease and diseases of expanded polyglutamine are associated with insoluble protein aggregates and neuronal death. A role for transglutaminase in the stabilization of these aggregates has been proposed. Diseases of polyglutamine expansion have been the most thoroughly investigated and a large body of studies supports the causative role of transglutaminase in aggregation of expanded polyglutamine. However none of the evidence is conclusive. Indisputable evidence of cross-linking by transglutaminase will be required in order to provide firm support for therapeutic measures based on the role of transglutaminase.
Keywords
- Enzyme
- Transglutaminase
- Polyglutamine
- Huntington's disease
- Alzheimer's disease
- Parkinson
- aggregates
- Review