Revista de Neurología (RN) is published by IMR Press from Volume 79 Issue 11 (2024). Previous articles were published by under the CC-BY-NC-ND licence, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement.
The neuropsychological profile of mild cognitive impairment with involvement of multiple cognitive areas. The importance of amnesia in distinguishing two subtypes of patients
M. Ferrer-Navajas , M.T. Frutos-Alegría , J.M. Moltó-Jordà , J. Morera-Guitart , A. Sánchez-Pérez
Article Info
Abstract
INTRODUCTION The use of diagnostic criteria for mild cognitive impairment (MCI) that do not require the presence of amnesia enables patients to be classified into three types of MCI: pure amnestic MCI (aMCI), MCI with involvement of multiple cognitive functions and amnesia (mf-aMCI) and MCI with involvement of multiple cognitive functions without amnesia, or non-amnestic MCI (mf-nonaMCI).
AIM To determine whether patients with MCI with involvement of multiple functions (mfMCI) have a different profile of cognitive involvement depending on whether amnesia is present or not.
PATIENTS AND METHODS Out of a total sample of 175 patients with MCI, we studied 138 with mfMCI. Of these, 109 (79%) had memory disorders (mf-aMCI) and 29 (21%) did not (mf-nonaMCI). For each group of patients, we determined the percentage who scored below normal in each of the items on the abbreviated Barcelona test.
RESULTS Patients with mf-aMCI failed more frequently in temporal orientation, naming and semantic category evocation tests. Patients with mf-nonaMCI failed more often in motor praxis and abstraction tests. Differences were statistically significant. Additionally, it was noted that patients with mf-nonaMCI tended to make more mistakes in attention tests.
CONCLUSIONS The presence of amnesia allows us to identify an mf-aMCI group with a cognitive profile suggesting temporal involvement, unlike the mf-nonaMCI group, whose members have a cognitive profile that suggests subcortical compromise.
AIM To determine whether patients with MCI with involvement of multiple functions (mfMCI) have a different profile of cognitive involvement depending on whether amnesia is present or not.
PATIENTS AND METHODS Out of a total sample of 175 patients with MCI, we studied 138 with mfMCI. Of these, 109 (79%) had memory disorders (mf-aMCI) and 29 (21%) did not (mf-nonaMCI). For each group of patients, we determined the percentage who scored below normal in each of the items on the abbreviated Barcelona test.
RESULTS Patients with mf-aMCI failed more frequently in temporal orientation, naming and semantic category evocation tests. Patients with mf-nonaMCI failed more often in motor praxis and abstraction tests. Differences were statistically significant. Additionally, it was noted that patients with mf-nonaMCI tended to make more mistakes in attention tests.
CONCLUSIONS The presence of amnesia allows us to identify an mf-aMCI group with a cognitive profile suggesting temporal involvement, unlike the mf-nonaMCI group, whose members have a cognitive profile that suggests subcortical compromise.
Keywords
- Alzheimer’s disease
- Mild cognitive impairment with involvement of multiple functions
- Non-amnestic mild cognitive impairment
- Pure amnestic mild cognitive impairment