†These authors contributed equally.
Background: The Serum creatinine/cystatin C ratio (Cr/CysC ratio) is an
emerging alternative index for muscle mass loss, a risk factor for cardiovascular
diseases (CVDs). However, the association between the Cr/CysC ratio and CVD
morbidity and mortality remains unknown. Methods: A total of 11,150
participants of the National Health and Nutrition Examination Survey (NHANES)
were included in this study. Univariable and multivariable logistic regression
models were employed to assess the association between the Cr/CysC ratio and
self-reported CVD morbidity. Cox proportional hazard models were
used to estimate the hazard ratio (HR) and 95% confidence interval (CI) of the
Cr/CysC ratio for CVD mortality. Results: At baseline, 1181 (7.90%)
participants had self-reported CVDs. Lower Cr/CysC ratios were found in
participants with CVDs (1.18