Exercise Training-Induced MicroRNA Alterations with Protective Effects in Cardiovascular Diseases

¹ Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, 226011 Nantong, Jiangsu, China

² Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Life Science, Shanghai University, 200444 Shanghai, China

³ Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA

⁴ Biologics Development, Sanofi, Framingham, MA 01701, USA

⁵ Department of Nursing, Union Hospital, Fujian Medical University Union Hospital, 350001 Fuzhou, Fujian, China

⁶ Fujian Provincial Special Reserve Talents Laboratory, Fujian Medical University Union Hospital, 350001 Fuzhou, Fujian, China

^*Correspondence: fjxhyjl@163.com (Yanjuan Lin); Junjiexiao@shu.edu.cn (Junjie Xiao)
^†These authors contributed equally.

Rev. Cardiovasc. Med. 2023, 24(9), 251; https://doi.org/10.31083/j.rcm2409251

Submitted: 19 January 2023 | Revised: 13 March 2023 | Accepted: 27 March 2023 | Published: 6 September 2023

(This article belongs to the Special Issue Advances with miRNAs in Cardiovascular Disease: miRNA-Based Therapeutic Strategies)

This is an open access article under the CC BY 4.0 license.

Abstract

Exercise training (ET) is an important non-drug adjuvant therapy against many human diseases, including cardiovascular diseases. The appropriate ET intensity induces beneficial adaptions and improves physiological function and cardiopulmonary fitness. The mechanisms of exercise-induced cardioprotective effects are still not fully understood. However, mounting evidence suggest that microRNAs (miRNAs) play crucial role in this process and are essential in responding to exercise-stress and mediating exercise-protective effects. Thus, this review summarizes the biogenesis of miRNAs, the mechanism of miRNA action, and specifically the miRNAs involved in exercise-induced cardio-protection used as therapeutic targets for treating cardiovascular diseases.

Keywords

exercise training

beneficial adaption

cardiovascular diseases

microRNA

therapeutic targets

Funding

82020108002/National Natural Science Foundation of China

82225005/National Natural Science Foundation of China

82170390/National Natural Science Foundation of China

21XD1421300/Science and Technology Commission of Shanghai Municipality

20DZ2255400/Science and Technology Commission of Shanghai Municipality

21ZR1422700/Science and Technology Commission of Shanghai Municipality

19SG34/“Dawn” Program of Shanghai Education Commission

Figures

Fig. 1.

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