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- Academic Editors
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Background: Left
bundle branch pacing (LBBP) is a relatively
novel physiological pacing strategy with
better electrocardiogram characteristics and pacing parameters than other pacing
strategies. At present, no meta-analysis or systematic review has examined the
risk of atrial fibrillation (AF) after LBBP compared to other pacing strategies.
Methods: We searched the PubMed, Embase, and Cochrane Library
databases from inception through September 18, 2022 to identify relevant studies
reporting AF incidence rates after LBBP. The incidence of AF following LBBP and
that associated with other pacing strategies were extracted and summarized for
the meta-analysis. We used odds ratios (ORs) and 95%
confidence intervals (CIs) as summary
estimates. Results: Five studies with 1144 participants were included.
The pooled rate of AF was 3.7% (95% CI, 0.8%–8.0%) in the LBBP group and
15.5% (95% CI: 9.6%–22.4%) in the other pacing strategies
(right ventricular pacing [RVP] and
biventricular pacing [BVP]). Compared with
other pacing strategies, LBBP was associated with a lower AF risk
(OR, 0.33; 95% CI: 0.22–0.51, I