§joint first authors.
Academic Editor: Konstantinos P. Letsas
Background: This study examined the clinical characteristics, genetic
basis, healthcare utilisation and costs of catecholaminergic ventricular
tachycardia (CPVT) patients from a Chinese city. Methods: This was a
territory-wide retrospective cohort study of consecutive CPVT patients at public
hospitals or clinics in Hong Kong. Healthcare resource utilisation for accident
and emergency (A&E), inpatient and outpatient attendances were analysed over 19
years (2001–2019) followed by calculations of annualised costs (in USD).
Results: Sixteen patients with a median presentation age (interquartile
range (IQR) of 11 (9–14) years old) were included. Fifteen patients (93.8%)
were initially symptomatic. Ten patients had both premature ventricular complexes
(PVCs) and ventricular tachycardia/fibrillation (VT/VF). One patient had PVCs without VT/VF. Genetic tests were
performed on 14 patients (87.5%). Eight (57.1%) tested positive for the ryanodine receptor 2 (RyR2)
gene. Seven variants have been described elsewhere (c.14848G