IMR Press / RCM / Volume 23 / Issue 5 / DOI: 10.31083/j.rcm2305178
Open Access Systematic Review
Hyperuricemia and Gout are Associated with the Risk of Atrial Fibrillation: An Updated Meta-Analysis
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1 Department of Cardiology, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, 361000 Xiamen, Fujian, China
*Correspondence: (Dong Chang)
Academic Editor: Buddhadeb Dawn
Rev. Cardiovasc. Med. 2022, 23(5), 178;
Submitted: 14 March 2022 | Revised: 24 April 2022 | Accepted: 27 April 2022 | Published: 16 May 2022
(This article belongs to the Special Issue Clinical Electrophysiology: Diagnosis and Treatment)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Background: Although it has been suggested that hyperuricemia and gout are predictive of the future risk of atrial fibrillation, there is still a lack of epidemiological evidence. Objective: Through an updated systematic review and meta-analysis, we aimed to assess the association between hyperuricemia/gout and atrial fibrillation. Methods: We performed a systematic search of EMBASE, PubMed, and Web of Science from their establishment to September 2021 for all relevant studies of hyperuricemia or gout and atrial fibrillation. Meta-analysis was conducted using the random-effects method to calculate the overall relative risk (RR) and 95% confidence intervals (CI), and subgroup analyses were performed on data subsets by geographic location and study design. Result: A total of 12 studies were included in this study. The results from 8 studies showed that hyperuricemia was associated with an increased incidence of atrial fibrillation (RR: 1.83, 95% CI: 1.35–2.47), but significant association was only observed in studies in China (RR: 1.88, 95% CI: 1.31–2.71) and cross-sectional studies (RR: 2.35, 95% CI: 1.97–2.81) rather than studies in Japan (RR: 1.74, 95% CI: 0.71–4.23) and cohort studies (RR: 1.20, 95% CI: 0.99–1.46). The results from 4 studies showed that gout was also associated with an increased risk of AF (RR: 1.33, 95% CI: 1.04–1.71). Conclusions: Hyperuricemia and gout are associated with an increased incidence of atrial fibrillation.

atrial fibrillation
systematic review
Fig. 1.
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