IMR Press / RCM / Volume 23 / Issue 5 / DOI: 10.31083/j.rcm2305172
Open Access Original Research
Maternal and Neonatal Outcomes in Pregnancy Complicated with Pulmonary Hypertension
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1 Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, 610041 Chengdu, Sichuan, China
2 Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, 610041 Chengdu, Sichuan, China
*Correspondence: (Haiyan Yu)
Academic Editor: Jane A. Leopold
Rev. Cardiovasc. Med. 2022, 23(5), 172;
Submitted: 2 February 2022 | Revised: 14 April 2022 | Accepted: 18 April 2022 | Published: 12 May 2022
(This article belongs to the Special Issue Cardiovascular Disease in Women)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Background: Pulmonary hypertension (PH) is a life-threatening disease with significant maternal morbidity and mortality. Methods: To assess pregnancy and neonatal outcomes and determine the risk factors for adverse maternal and neonatal outcomes in women with pulmonary hypertension (PH), a retrospective analysis was carried out examining 71 pregnancies in patients with PH who delivered at a tertiary care center in West China between January 2011 and May 2016. Results: One pregnancy resulted in spontaneous abortion and six resulted in terminated abortions. Cardiac complications were encountered in 16.9% including three maternal mortalities. At least one pregnancy complication occurred in 28.2% of all the pregnancies. Diagnosis after the third trimester, severe PH and/or right ventricular systolic dysfunction were predictive of adverse fetal/neonatal events. A history of prior cardiac events and right ventricular systolic dysfunction and/or baseline New York Heart Association (NYHA) class III or IV were the main predictive factors of adverse maternal cardiac events. Conclusions: In our study, we found that PH poses high risks for maternal and fetal morbidity and mortality. A detailed pre-pregnancy baseline assessment is strongly recommended in women with PH to identify those with the highest risk and subsequently guide clinical management.

pulmonary hypertension
heart disease
pregnancy complication
maternal and neonatal outcomes
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