IMR Press / RCM / Volume 23 / Issue 3 / DOI: 10.31083/j.rcm2303079
Open Access Original Research
Effect of lipoprotein(a) levels on long-term outcome in octogenarians with coronary artery disease after drug-eluting stent implantation
Bin Hu1,2,3Yujie Zhou1,2,3,*Dongmei Shi1,2,3Yingxin Zhao1,2,3Dean Jia1,2,3Shiwei Yang1,2,3Shuo Jia1,2,3Xiaohan Xu1,2,3Xiaoteng Ma1,2,3
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1 Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China
2 Beijing Institute of Heart, Lung and Blood Vessel Diseases, 100029 Beijing, China
3 The Key Laboratory of Remodeling-related Cardiovascular Disease, Ministry of Education, 100029 Beijing, China
*Correspondence: azzyj12@163.com (Yujie Zhou)
Academic Editors: Carmela Rita Balistreri and Calogera Pisano
Rev. Cardiovasc. Med. 2022, 23(3), 79; https://doi.org/10.31083/j.rcm2303079
Submitted: 22 October 2021 | Revised: 20 December 2021 | Accepted: 21 December 2021 | Published: 1 March 2022
(This article belongs to the Special Issue New Frontiers in Cardiac Surgery: Biomarkers and Treatment)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

Background: High levels of lipoprotein(a) [Lp(a)] are linked to adverse cardiovascular events. The significance of Lp(a) for the survival of octogenarians with coronary artery disease (CAD) after drug-eluting stent (DES) insertion is, however, not known. The purpose of the study is to investigated the connection between Lp(a) and outcome in octogenarians with CAD after DES implantation. Methods: We retrospectively enrolled a total of 506 consecutive octogenarians with CAD and DES implantation in our institution between January 2015 to August 2018. Two patient groups were established: a low group with plasma Lp(a) lower than 50 mg/dL (n = 408) and a high group with values above 50 mg/dL (n = 98). Results: After following up for a median of 31.53 ± 8.22 months, Kaplan-Meier curves indicated that poorer outcome censored for major cardiovascular events (MACE), myocardial infarction (MI), and target vessel revascularization (TVR) in the high group relative to the low group (log-rank test p = 0.001, p = 0.008, and p < 0.001, respectively). High Lp(a) independently predicted MACE (hazard ratio (HR) 1.90; 95% confidence interval (CI) 1.28–2.84; p = 0.002), MI (HR 2.74; 95% CI 1.23–6.11; p = 0.014), and TVR (HR 3.65; 95% CI 1.99–6.69; p < 0.001) after covariate adjustment. Conclusions: High Lp(a) was also significantly related to poor long-term outcome in octogenarians with CAD after DES implantation.

Keywords
Lipoprotein(a)
Coronary artery disease
Drug-eluting stent
Octogenarian
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