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3-Alkyl- and 3-aryl-7H-furo[3,2-g]chromen-7-ones as blockers of the voltage-gated potassium channel Kv1.3
A. Wernekenschnieder 1, P. Körner 1, W. Hänsel 2
Affiliations
Article Info
1 Pharmazeutisches Institut, Universität Kiel, Kiel, Germany
2 Pharmazeutisches Institut, Universität Kiel, Gutenbergstr. 76, Kiel, 24118, Germany, Email: whaensel@pharmazie.uni-kiel.de
Abstract
3-Alkyl- and 3-aryl-7H-furo[3,2-g]chromen-7-ones were synthesised and studied for their effects on voltage-gated K+ and Na+ channels of the neuroblastoma cell-line N1E-115 and K+ channels of L-929 mouse-fibroblasts, stably transfected with mKv1.3. All furocoumarins tested showed Kv channel blocking activities, the most potent one in a half-blocking concentration of 0.7 μM.