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HPLC assay in plasma and preliminary pharmacokinetic study of a quinazolinone derivative with spasmolytic effect
P. Kastner 1, J. Klimeš 2, M. Lázníček 2, Th. Jira 3
Affiliations
Article Info
1 Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Heyrovského 1203, Hradec Králové, CZ-500 05, Czech Republic
2 Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic
3 Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany
Abstract
An analytical method for analysis of 3-(o-bromo)-phenyl-2-(2′,3′-dihydroxypropylthio)-4(3H)-quinazolinone from rat plasma using HPLC with reversed phase C18 and liquid-liquid extraction was developed. This method was used for a pharmacokinetic study in rat.