Die Pharmazie is published by IMR Press from Volume 81 Issue 1 (2026). Previous articles were published by another publisher under the CC-BY licence, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement.
Synthesis and pharmacological investigation of some novel 2,3-disubstituted quinazolin-4(3H)-ones as analgesic and antiinflammatory agents
V. Alagarsamy 1, S. Meena 2, S. Vijayakumar 2, K. V. Ramseshu 2, R. Revathi 3
Affiliations
Article Info
1 Medicinal Chemistry Laboratory, S. B. College of Pharmacy, Madurai, Sivakasi, 626130, India, Email: samy_veera@yahoo.com
2 Sivakasi Department of Pharmaceutical Chemistry, K. M. College of Pharmacy, Madurai, India
3 Medicinal Chemistry Laboratory, S. B. College of Pharmacy, Madurai, India
Abstract
A series of novel 2-substituted quinazolin-4(3H)-ones have been synthesized by condensing the aromatic primary amine of 2-substituted quinazolines with different aldehydes and ketones. The synthesized compounds were confirmed by their spectral data (IR, NMR and MS) and the purity was ascertained by elemental analysis. When these compounds were evaluated for analgesic and antiinflammatory activities, compounds I–VIII exhibited more potent analgesic activity than diclofenac sodium, while the compounds IV, V, VI and VII exhibited more potent antiinflammatory activity than diclofenac sodium. The activity values were found to be significant as compared to those of controls.